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Grant Bio Personal Multi-Channel Bioreactor

Item #: ASMULTIBIOREACT 

Specifications

Item #

RTS-8

RTS-8-PLUS

Light source

Laser

Measurement wavelength (λ)

850 ± 15 nm

Measurement range

0-100 OD600

E.coli factory calibration measurement range

0-50 OD600

S.cerevisiae factory calibration measurement range

0-75 OD600

Achievable user calibration measurement error
  (range 0.1-6 OD600)

± 0.3

Achievable user calibration measurement error
  (range 6-50 OD600)

≤ 5%

Achievable user calibration measurement error
  (range 50-75 OD600)

≤ 10%

Measurement periodicity per hour

1 - 60

Temperature setting range

+15°C ... +60°C

Temperature control range

+15 °C below ambient ... +60 °C

Temperature stability

±0.3 °C

Sample temperature accuracy (20°C – 37°C)

±1 °C

Tube sockets

8

Sample working volume range

3–50 mL

Speed control range

150–2700 rpm

Reverse spin time setting range 150-250 rpm

0 s

Reverse spin time setting range 250–300 rpm

2-60 s

Reverse spin time setting range 300–2700 rpm

0-60 s

Display

0-60 s LCD

Minimum PC requirements

Intel/AMD Processor, 1 GB RAM, Windows Vista/7/8/8.1/10/11, USB 2.0 port

Dimensions (W×D×H)

350 × 690 × 300 mm

Weight

20 kg

Nominal operating voltage

AC 230 V, 50 Hz

Power consumption

3.15 A / 500 W

02 sensor

N/A

+

Range

N/A

0-100%

Accuracy

N/A

±0.05% O2 at 0.2%, ±0.4% O2 at 20.9%

Drift

N/A

<0.03% O2 within 30 days

Temperature range

N/A

up to 40°C

Response time (t90)

N/A

6s

Storage stability

N/A

18 months

pH sensor

N/A

+

Range

N/A

4.0 - 8.5 pH

Accuracy

N/A

±0.10 pH at pH 7

Drift

N/A

<0.005 pH per day

Temperature range

N/A

up to 40°C

Response time (t90)

N/A

<120 s

Storage stability

N/A

18 months

Grant Bio Personal Multi-Channel Bioreactors - RTS-8 and RTS-8-PLUS 

 

Personal multi-channel bioreactors with non-invasive real-time OD, pH, and pO2 measurements.

Please specify which calibration option is desired upon placing order (E.coli, S.Cerevisiae, or both E.Coli and S.Cerevisiae calibration).

 

About

RTS-8 and RTS-8 plus are personal bioreactors that utilize patented Reverse-Spin® technology that applies non-invasive, mechanically driven, low energy consumption, innovative type of agitation where cell suspension is mixed by the single-use falcon bioreactor tube rotation around its axis with a change of direction of rotation motion resulting in highly efficient mixing and oxygenation for aerobic cultivation. Combined with near-infrared, fluorescence, and luminescence measurement systems, it is possible to register cell growth kinetics, pH, and O2 non-invasively in real time. For pH and O2, innovative single-use sensor spots are used inside the tubes.

 

Although O2 supply is one of the major issues in the cultivation of aerobic organisms, especially in oxygen-limited conditions, adequate methods for real monitoring of dissolved oxygen were missing, and sufficient O2 supply was usually assumed. Innovative non-invasive oxygen sensors integrated in falcon tubes now enable online oxygen monitoring and give new insights into metabolic activities. The pH is one of the major issues in the cultivation of cells, yeast, or bacteria. Cultivation vessels that are sensor-limited are widely applied in academic and industrial bioprocess development. As adequate methods for real monitoring of pH were not available, cumbersome at-line sampling was used lacking high data density and interfering with growth. Non-invasive real-time pH measurement provides new insights into metabolic activity and changes in metabolic pathways.

 

Features

  • Parallel cultivation of 8-tube bioreactors enables to save time and resources for bioprocess optimization
  • Individually controlled bioreactor accelerates optimization process
  • Possibility to cultivate microaerophilic and obligate anaerobic microorganisms (not strict anaerobic conditions)
  • Reverse-Spin® mixing principle enables non-invasive biomass measurement in real time
  • The near-infrared optical system makes it possible to register cell growth kinetics
  • Free-of-charge software for storage, demonstration, and analysis of data in real-time
  • Compact design with low profile and small footprint for personal application
  • Individual temperature control for bioprocess applications
  • Active cooling for rapid temperature control, e.g. for temperature fluctuation experiments
  • Task profiling for process automatization
  • Cloud data storage to remotely monitor the process of cultivation while at home or using a mobile phone
  • For the plus model - Non-invasive O2 and pH measurement allows for accurate monitoring of metabolic activities

 

Software Features

  • Real-Time cell growth logging
  • Real-Time pH and O2 measurement and logging (RTS-8-Plus)
  • 3D graphical representation of OD or growth rate over time over unit
  • Pause option
  • Save/Load option
  • Report option: PDF and Excel
  • Remote monitoring option (requires internet connection)
  • Cycling/Profiling options
  • User manual calibration possibility for most cells

To fully use RTS-8 Plus capabilities, the device must be connected to a PC and RTS-8 software. The device cannot be used as a standalone unit.
 
 

Applications

  • Fermentation real-time growth kinetics
  • Clone candidate screening
  • Protein expression
  • Temperature stress and fluctuation experiments
  • Media screening and optimization
  • Growth characterization
  • Inhibition and toxicity tests
  • Strain quality control
  • Initial bioprocess optimization studies   

 
 

 
 
 
SKU Number Type Capacity/Volume Price Quantity Add to Cart
RTS-8-US Multi-channel, real-time OD 8 Tubes / 3 - 50 mL
18977.00
Each
RTS-8-PLUS-US Multi-channel, real-time OD, pH, & pO2 8 Tubes / 3 - 50 mL
42966.00
Each
RTS-8 Personal Bioreactor
Grant Bio Personal Multi-Channel Bioreactor
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