PR1MA™ Phleomycin, Powder

CAS Number: 11006-33-0
Molecular Weight: 1525
Chemical Formula: C₅₅H₈₅O₂₁N₂₀S ₂Cu • HCl
Solubility: Water
Storage Temp: 2-8°C

Produced by Streptomyces verticillus and part of the structurally related group of Bleomycin/Phleomycin type antibiotics. Used as a selective agent in transformation experiments with mammalian cells, plant cells, and yeast. Cytotoxic action of this type of antibiotic results from the ability to cause fragmentation of DNA. In Vitro studies indicate that Phleomycin causes the accumulation of cells in the G2 phase of the cell cycle.

Research or further manufacturing use only, not for food or drug use.

• Appearance: Light Blue Powder
• U.V. Absorbance (244nm, 600 µg/ml, 0.1cm Path): 0.20 - 0.30
• Storage Condition: Store at 2 - 8 ^oC (Very Hygroscopic: Keep container tightly sealed until ready for use).

• Appearance: White, greyish-white or yellowish-white, fine, crystalline powder or fine crystals, needles or elongated plates
• Identification: Pass
• Melting Point: 149 - 153 ^oC
• pH: 4.5 - 7.5
• Specific Optical Rotation: +17.0 - +20.0^o
• Chloride: ≤ 0.01 %
• Related Substances: ≤ 0.50 %
• Loss on Drying: ≤ 0.50 %
• Sulfated Ash: ≤ 0.10 %
• Assay (Dried Basis): 98.0 - 102.0 %
• Non Animal Origin: Non Animal Origin
• Grade: USP
• Country of Origin: Report

CAS Number: 66-81-9
Molecular Weight: 281.35
Chemical Formula: C₁₅H₂₃NO₄
Solubility: Ethanol, methanol
Storage Temp: 2-8°C

Antifungal antibiotic that inhibits protein synthesis in eukaryotes. Blocks translation of mRNA on the ribosome derived from Streptomyces griseus.

WARNING! This product can expose you to Cycloheximide, a chemical which is known to the State of California to cause developmental harm. For more information go to www.P65Warnings.ca.gov.

Research or further manufacturing use only, not for food or drug use.

• Appearance: White to Off White Crystalline Powder
• HPLC (Purity): ≥ 96.0 %
• Identification (HPLC): Conforms
• Melting Point: 102 - 120 ^oC
• Potency: ≥ 950 µg/mg
• Solubility: Soluble In Chloroform; Ethanol, Methanol
• Water Content: < 0.3 %

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• Appearance: Yellow Crystalline Powder
• Crystallinity: Pass
• Identification: Pass
• Loss on Drying: ≤ 2.0 %
• pH (1% Solution in Water)@ 25°C: 2.3 - 3.3
• Potency: ≥ 900 µg/mg
• Specific Rotation: -250 - -235°

PR1MA™ Streptomycin Sulfate

• Appearance: Fine White Powder
• Appearance of Solution: Clear
• Abnormal Toxicity: Meets The Requirements
• Bacterial Endotoxins : ≤ 0.25 IU/mg
• Colorimetric: ≥ 90.0 %
• Identification: Complies
• Loss on Drying (EP): ≤ 7.0 %
• Loss on Drying (USP): ≤ 5.0 %
• Methanol (GC): ≤ 0.3 %
• pH: 4.5 - 7.0
• Potency (Dried basis): ≥ 720 µg/mg
• Residual Solvents: No Class 1, 2, 3 or other residual solvents are present
• Streptomycin B: ≤ 3.0 %
• Sulfate: 18.0 - 21.5 %
• Sulfated Ash: ≤ 1.0 %
• BSE/TSE: BSE/TSE Free