TPP TubeSpin® Bioreactors

TPP TubeSpin® Bioreactors have a proven track record in large-scale screening and optimization processes of suspension cells. Designed for efficiency, these tubes allow evaluation of parameters important for production up-scaling while using minimal culture volumes—maximizing the number of parallel experiments possible at the same time.

Suspension cells ranging from immune cells to insect cells, and microorganisms such as E. coli and yeast, can be both cultured and centrifuged directly in TubeSpin® Bioreactors, eliminating the need for transfers before spinning down.

Key Features

• Working volume: 1–35 mL
• Start small suspension cell cultures directly from frozen stocks
• Suitable for bacterial, yeast, and suspension cell cultures (static or shaking)
• Conical bottom for easy pelleting
• 0.22 µm PTFE filter membrane for sterile gas exchange
• Five adjustable openings (A–E) to regulate ventilation as needed
• Fits in standard 15 mL centrifuge rotors
• Dual-purpose: culture and spin in the same tube
• Saves on consumables compared to Erlenmeyer flasks and transfer tubes

Advantages

• Superior gas exchange and defined ventilation control
• Flexible working volumes with one tube type
• Eliminates transfer steps — centrifuge cultures directly
• Enables large-scale, parallel experiments
• Minimizes cell shearing and foam formation (no stirring mechanism)
• Space-saving compared to T-flasks
• Reduces plastic use and waste
• Easy sampling and withdrawal

Applications: Bacterial & Microbiological Cultures

• TPP TubeSpin® Bioreactors are ideally suited for bacteria, yeast, and other microorganisms. Compared to traditional glass test tubes, these disposable tubes save time and effort by eliminating washing and sterilization steps.
• Support aerobic and anaerobic cultures via adjustable filter cap openings
• Culture 1–35 mL volumes per tube — ideal for mini preps, small-scale screens, and downstream workflows
• Disposable format ensures fast setup and reduced contamination risk
• Compatible with CO shaking incubators for parallel high-throughput cultivation

Water Loss Minimization

• When incubating small culture volumes for extended periods, water loss can affect growth. 
• TubeSpin® Bioreactors allow control of evaporation by selectively closing openings above the sterile PTFE filter membrane, while still ensuring effective gas exchange.

Quality Assurance

• Manufactured from high-quality, optically clear plastic
• Sterile, gamma irradiated
• Certified DNase/RNase, nucleic acid, and pyrogen-free

Contact us for free samples and explore how TPP TubeSpin® Bioreactors can streamline your cell culture workflows.   

Literature and comprehensive information about shaking technology can be found in the "Forum Shaking Technology", a cooperation of TPP with competent partner companies.